Volatile and Non-Volatile Content Determination and Biological Activity Evaluation of Fresh Humulus lupulus L. (cv. Chinook) Leaves and Inflorescences

نویسندگان

چکیده

In this work, the fresh leaves and inflorescences of Humulus lupulus L. cv. Chinook hops were investigated in order to describe their chemical composition evaluate biological activities. The analyses carried out first on untreated samples then pulverized ones using SPME-GC-MS technique. total, forty-two molecules belonging different classes identified, among these, twenty-three terpene compounds. carry activity assays, powders subjected extraction with two solvents (methanol distilled water) by stirring subsequent sonication at room temperature. To chemically characterize extracts, methanolic analyzed direct injection into GC-MS apparatus, while aqueous DI-SPME-GC-MS. addition, aim obtain information non-volatile content they also derivatization, silylated derivatives GC-MS. antioxidant was evaluated means DPPH ABTS assays after determination total polyphenols flavonoids. greatest effects observed extracts rather than ones. Furthermore, a preliminary study cytotoxic power conducted three human cancer cell lines, such as non-small lung (H1299), melanoma (A375) breast (MCF7). obtained results showed that induced marginal effect reducing tumor, proliferation.

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ژورنال

عنوان ژورنال: Separations

سال: 2023

ISSN: ['2297-8739']

DOI: https://doi.org/10.3390/separations10020091